What is Facial Rejuvenation with Stem Cells and Nanofat?
Facial rejuvenation with stem cells; It is a biological repair method that revolutionized aesthetic surgery with the discovery in 2001 that fat cells are a rich source. Unlike traditional methods, in this process, fat cells are specially processed and injected under the skin to reverse cellular aging.
Scientific Fact: It has been proven that there are no fat cells left in nanofat and it is primarily composed of stem cells. Facial rejuvenation with stem cells The aim in applications is not just to fill, but to biologically repair the tissue.

Facial rejuvenation application with nanofat and stem cells.
Contents
ToggleWhen Do the Rejuvenating Effects of Stem Cells Begin?
Rejuvenation with stem cells the effects of the process are generally between 1-3 months begins to be seen. The effects of revitalizing the skin, reducing blemishes, and tightening settle in this process. It is injected into every skin section with very fine needles, targeting the upper layer wrinkles, damaged, thinned, and quality-reduced skin. Nanofat application does not swell the face, it provides a natural youthfulness.
What Are the Application Steps?
Hundreds of trillions of cells make up the human body. This process basically consists of three steps:
- Stem Cell Harvesting: The best source for these special cells is adipose tissue. Through an apheresis process, these cells are separated from the adipose tissue within 1-2 hours.
- Application Technique: It should be done considering the proportions, priorities, and anatomy of the face.
- Awakening Processes: It is the step where growth factors are used to awaken and direct the stem cells made.
Is Facial Rejuvenation with Stem Cells Permanent?
The topic our patients are most curious about is: Is facial rejuvenation with stem cells permanent? Yes, the effect is permanent as long as the transferred cells live. However, since time does not stop, the aging process continues. In the literature and our clinical observations, the protective biological effect of this procedure is on average 5 years It is accepted to last. During this period, skin quality is much better preserved compared to its untreated state.
Repair After Facial Rejuvenation with Stem Cells
When there is an injury somewhere, chemical substances called “Chemokines” are released. Receptors, which we call sensors on stem cells, are sensitive to this substance. Stem cells that detect chemokines quickly go to the site of damage and start the repair.
History of the Treatment
The use of stem cell therapy in the health field dates back a long time. What is relatively new is the recognition of the value of adipose tissue-derived stem cells. Stem cells, which are more difficult to obtain from bone marrow, have started to be obtained easily from adipose tissue and almost 1000 times as much as from bone marrow.
Facial Shaping and Aesthetic Perspective
Without the correct perspective of an aesthetic surgeon, facial and body rejuvenation does not yield sufficient results. The aesthetic surgeon makes a plan considering the needs, weak points, and strategic areas of the face and body.
Importance of Fat Tissue for Facial Rejuvenation with Stem Cells
As long as fat tissue is in the right place and amount, it provides youth and health. Unfortunately, recent trends, especially among women, are to get rid of as much fat tissue as possible. This negative trend leads to issues such as premature aging and loss of feminization in women. Fat tissue is the richest and easiest source of stem cells.
Facial Rejuvenation with Stem Cells in Men and Women
The effects of this application (obtained from fat) are more pronounced in the older age group (60 and above). In the middle age group, since women experience earlier deterioration in their skin structure, although more noticeable results are obtained for women due to the suitability of the feminine structure for rejuvenation by adding volume, it is also effective in men.
Combined Use of Nanofat and Stem Cells for Facial Rejuvenation
In their scientific study published in 2019 (Aesth Surg J), Zheng and colleagues demonstrated that nanofat application corrects aging due to sun damage. In this respect, nanofat is a very valuable application. Similar biological repair effects Exosome Therapy can also be supported with.
Scientific References and Bibliography
- İnsan yağ dokusu kaynaklı mezenkimal kök hücrelerin progresif hemifasiyal atrofi üzerindeki klinik uygulaması. (Koh KS, Oh TS, et al. Ann Plast Surg. 2012)
- Sistemik skleroz hastalarında yüz engelinde otolog mikroyağ greftinin etkinliği. (Sautereau N, Daumas A, et al. Plast Reconstr Surg Glob Open. 2016)
- Nanoyağ greftleme: temel araştırma ve klinik uygulamalar. (Tonnard P, Verpaele A, et al. Plast Reconstr Surg. 2013)
Frequently Asked Questions
How much is skin rejuvenation with stem cells?
Pricing varies according to the scope of the procedure (is it just the face, or does it include the neck and décolleté?), the technology to be used (Nanofat, SVF), and additional combined procedures. A clinical examination is required for exact pricing information due to legal regulations.
How many sessions for facial stem cells?
Generally a single session is sufficient. However, depending on the condition of the skin damage, the patient's age, and smoking habits, reminder sessions may be conducted in the following years to enhance the effectiveness of the procedure.
Do stem cells rejuvenate?
Absolutely, it provides a biological repair by triggering collagen production in the skin. It improves skin quality, reduces fine wrinkles, and restores the lost radiance to the skin.
How many years are stem cells permanent?
The effects of stem cell therapy obtained from fat tissue are quite long-lasting. In the literature and our clinical observations, the protective effect of this procedure approximately 5 years it is known to last.
What is the lifespan of a stem cell?
The transferred cells are permanent, but since the aging process continues, the biological effect is considered to be an average of 5 years.
How many days does it take for stem cells to heal?
Since the procedure is not a surgical operation, the recovery time is very short. There may be slight swelling or redness in the treated area lasting 1-3 days, and the patient can immediately return to social life.
How is facial stem cell treatment done?
The procedure is performed under local anesthesia. A small amount of fat is first taken from the patient's abdomen or leg area with special cannulas. This fat is processed in a laboratory environment through special procedures (Nanofat or SVF) to isolate stem cells and is injected into the face.
Dr Karacalar's Books
To examine Prof. Dr. Ahmet Karacalar's philosophy of aesthetic surgery and the scientific works he has written Dr Karacalar's Books You can visit the page.
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